BDBM33411 β-Thujaplicinol::hydroxytropolone, 3

SMILES CC(C)c1ccc(O)c(=O)c(O)c1

InChI Key InChIKey=HVGNSPLLPQWYGC-UHFFFAOYSA-N

Data  9 IC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 33411   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Gilead Sciences

LigandPNGBDBM33411(β-Thujaplicinol | hydroxytropolone, 3)
Affinity DataIC50:  660nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Mcgill University

LigandPNGBDBM33411(β-Thujaplicinol | hydroxytropolone, 3)
Affinity DataIC50:  3.80E+3nMpH: 7.8 T: 2°CAssay Description:To compare activity and inhibition of E. coli RNase H with HIV-1 RNase H, theconcentration of the E. coli was adjusted to the efficiency of 500 nM HI...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Food And Drug Administration

Curated by ChEMBL
LigandPNGBDBM33411(β-Thujaplicinol | hydroxytropolone, 3)
Affinity DataIC50:  260nMAssay Description:Inhibition of human immunodeficiency virus-1 reverse transcriptase associated RNase H activity using using 18-nucleotide 3,-fluorescein-labeled RNA s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 2)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM33411(β-Thujaplicinol | hydroxytropolone, 3)
Affinity DataIC50:  250nMAssay Description:Inhibition of RNase H activity of HIV-2 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Gilead Sciences

LigandPNGBDBM33411(β-Thujaplicinol | hydroxytropolone, 3)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant His-tagged wild-type HIV-1 group M subtype B BH10 reverse transcriptase-associated RNase H activity harboring p66/p51 hetro...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Food And Drug Administration

Curated by ChEMBL
LigandPNGBDBM33411(β-Thujaplicinol | hydroxytropolone, 3)
Affinity DataIC50:  210nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Gilead Sciences

LigandPNGBDBM33411(β-Thujaplicinol | hydroxytropolone, 3)
Affinity DataIC50:  1.98E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase H activity expressed in Escherichia coli using 32P-labeled template 31Trna RNA and DNA oligonucleotide...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Gilead Sciences

LigandPNGBDBM33411(β-Thujaplicinol | hydroxytropolone, 3)
Affinity DataIC50:  1.98E+3nMAssay Description:Inhibition of wild-type recombinant HIV-1 group M subtype B BH10 reverse transcriptase RNase-associated RNase H activity expressed in Escherichia col...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Gilead Sciences

LigandPNGBDBM33411(β-Thujaplicinol | hydroxytropolone, 3)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of HIV-1 BH10 reverse transcriptase RNase H activity expressed in Escherichia coli using [32P]-labeled template primer 31Trna/21P as subst...More data for this Ligand-Target Pair