BDBM334160 9-ethyl-6-({(3S)-1-[(3- methoxyazetidin-1- yl)carbonyl]pyrrolidin-3- yl}oxy)-8-(2-methylpyrimidin- 5-yl)-9H-purine::US9730940, Compound 5-13

SMILES CCn1c(nc2c(O[C@H]3CCN(C3)C(=O)N3CC(C3)OC)ncnc12)-c1cnc(C)nc1

InChI Key InChIKey=DRYBLTNKIICECT-HNNXBMFYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 334160   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM334160(9-ethyl-6-({(3S)-1-[(3- methoxyazetidin-1- yl)carb...)
Affinity DataIC50:  1.80nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM334160(9-ethyl-6-({(3S)-1-[(3- methoxyazetidin-1- yl)carb...)
Affinity DataIC50:  63nMAssay Description:Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in anti-IgM-antibody-induced phosphorylation of AKT at Ser473 residue preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM334160(9-ethyl-6-({(3S)-1-[(3- methoxyazetidin-1- yl)carb...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed