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BDBM335435 N-(Cyclopropylmethyl)-4-piperazin-1-ylpyridin-2-amine::US9732087, 35

SMILES: C(Nc1cc(ccn1)N1CCNCC1)C1CC1

InChI Key: InChIKey=UZLHBGZXOOPWEB-UHFFFAOYSA-N

Data: 1 KI

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 335435   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM335435
PNG
(N-(Cyclopropylmethyl)-4-piperazin-1-ylpyridin-2-am...)
Show SMILES C(Nc1cc(ccn1)N1CCNCC1)C1CC1
Show InChI InChI=1S/C13H20N4/c1-2-11(1)10-16-13-9-12(3-4-15-13)17-7-5-14-6-8-17/h3-4,9,11,14H,1-2,5-8,10H2,(H,15,16)
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
US Patent
25.6n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA N.V.

US Patent


Assay Description
Cell pellets from SK-N-MC cells stably or transiently transfected with human H4 receptor (NCBI accession No. AF312230) were used for the binding assa...


US Patent US9732087 (2017)


Article DOI: 10.1021/jm060807n
More data for this
Ligand-Target Pair