BDBM335480 4-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl-1,1- dioxido-3,6-dihydro-2H-1,4- thiazin-3-yl)-5-fluoropyridin-2- yl)amino)pyrido[3,2- d]pyrimidine-7-carbonitrile::US9732088, Example 39

SMILES C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2ncnc3cc(cnc23)C#N)ncc1F

InChI Key InChIKey=CVMPFRWKSSVYBK-VXKWHMMOSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 335480   

TargetBeta-secretase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM335480(4-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...)
Affinity DataKi:  13nMAssay Description:The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM335480(4-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...)
Affinity DataKi:  19nMAssay Description:The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM335480(4-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...)
Affinity DataKi: >9.40E+3nMAssay Description:The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent