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BDBM335558 US9737525, Compound MIND4-17-56

SMILES: [O-][N+](=O)c1cnc(Sc2nnc(-c3ccc(Cl)cc3)n2-c2ccccc2)c(Br)c1

InChI Key: InChIKey=OUYVUKMCCOSDOD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 335558   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NAD-dependent deacetylase sirtuin 2


(Homo sapiens (Human))
BDBM335558
PNG
(US9737525, Compound MIND4-17-56)
Show SMILES [O-][N+](=O)c1cnc(Sc2nnc(-c3ccc(Cl)cc3)n2-c2ccccc2)c(Br)c1
Show InChI InChI=1S/C19H11BrClN5O2S/c20-16-10-15(26(27)28)11-22-18(16)29-19-24-23-17(12-6-8-13(21)9-7-12)25(19)14-4-2-1-3-5-14/h1-11H
PDB
MMDB

NCI pathway
KEGG

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The General Hospital Corporation; The Regents of the University of California

US Patent


Assay Description
Modulation of sirtuin activity by compounds was assessed using the Flour de Lys fluorescent biochemical assay in a 96-well format as described (Outei...


US Patent US9737525 (2017)

More data for this
Ligand-Target Pair