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BDBM336283 US9744172, Compound UNC1057A

SMILES: O[C@H]1CCC(CC1)n1nc(-c2ccc(cc2)N2CCOCC2)c2cnc(NCCC(F)(F)F)nc12

InChI Key: InChIKey=DMIDDBSHOVHYJI-HSNGWXBGSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336283   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336283
PNG
(US9744172, Compound UNC1057A)
Show SMILES O[C@H]1CCC(CC1)n1nc(-c2ccc(cc2)N2CCOCC2)c2cnc(NCCC(F)(F)F)nc12
Show InChI InChI=1S/C24H29F3N6O2/c25-24(26,27)9-10-28-23-29-15-20-21(16-1-3-17(4-2-16)32-11-13-35-14-12-32)31-33(22(20)30-23)18-5-7-19(34)8-6-18/h1-4,15,18-19,34H,5-14H2,(H,28,29,30)/t18?,19-
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair