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BDBM336376 US9744172, Compound UNC1029A

SMILES: CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)Nc1ccc(F)cc1

InChI Key: InChIKey=GXWFXXCSKZZNLX-RAKDUWMASA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336376   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336376
PNG
(US9744172, Compound UNC1029A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C27H31FN6O3S/c1-2-3-16-29-27-30-17-24-25(32-34(26(24)31-27)21-10-12-22(35)13-11-21)18-4-14-23(15-5-18)38(36,37)33-20-8-6-19(28)7-9-20/h4-9,14-15,17,21-22,33,35H,2-3,10-13,16H2,1H3,(H,29,30,31)/t21?,22-
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PC cid
PC sid
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US Patent
n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair