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BDBM336421 US9744172, Compound UNC1170A

SMILES: CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)N1CCOCC1

InChI Key: InChIKey=VGUHPVVNZMUGLX-XVUZFVQRSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336421   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336421
PNG
(US9744172, Compound UNC1170A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H37N7O2/c1-2-3-12-29-27-30-17-23-24(32-34(25(23)31-27)18-19-4-10-22(28)11-5-19)20-6-8-21(9-7-20)26(35)33-13-15-36-16-14-33/h6-9,17,19,22H,2-5,10-16,18,28H2,1H3,(H,29,30,31)/t19?,22-
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PC cid
PC sid
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US Patent
n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair