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BDBM336437 US9744172, Compound UNC1174A

SMILES: CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC1CCN(CC1)C(=O)OC(C)(C)C

InChI Key: InChIKey=SAWNJHFIWLCVOD-PCXKSQOTSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336437   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336437
PNG
(US9744172, Compound UNC1174A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C32H47N7O5S/c1-5-6-17-33-30-34-21-27-28(37-39(29(27)36-30)24-9-11-25(40)12-10-24)23-7-13-26(14-8-23)45(42,43)35-20-22-15-18-38(19-16-22)31(41)44-32(2,3)4/h7-8,13-14,21-22,24-25,35,40H,5-6,9-12,15-20H2,1-4H3,(H,33,34,36)/t24?,25-
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair