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BDBM336450 US9744172, Compound UNC1192A

SMILES: CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)NCCC)cc1

InChI Key: InChIKey=FKCQWLUGUDJKAA-GUAVBDGJSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336450   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336450
PNG
(US9744172, Compound UNC1192A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)NCCC)cc1
Show InChI InChI=1S/C25H35N7O2/c1-3-5-15-26-24-28-16-21-22(17-6-8-18(9-7-17)29-25(34)27-14-4-2)31-32(23(21)30-24)19-10-12-20(33)13-11-19/h6-9,16,19-20,33H,3-5,10-15H2,1-2H3,(H,26,28,30)(H2,27,29,34)/t19?,20-
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PC cid
PC sid
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Article
US Patent
n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)


Article DOI: 10.1073/pnas.0504952102
BindingDB Entry DOI: 10.7270/Q2PR7Z30
More data for this
Ligand-Target Pair