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BDBM336454 US9744172, Compound UNC1142A

SMILES: CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(CC)CC1

InChI Key: InChIKey=QZDAKXDADYSIIL-RAKDUWMASA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336454   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336454
PNG
(US9744172, Compound UNC1142A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C27H39N7O3S/c1-3-5-14-28-27-29-19-24-25(31-34(26(24)30-27)21-8-10-22(35)11-9-21)20-6-12-23(13-7-20)38(36,37)33-17-15-32(4-2)16-18-33/h6-7,12-13,19,21-22,35H,3-5,8-11,14-18H2,1-2H3,(H,28,29,30)/t21?,22-
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MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair