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BDBM336491 US9744172, Compound UNC1319A

SMILES: CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCc1ccc(F)cc1

InChI Key: InChIKey=KWFJXHUAMNVCHZ-SSYJEGPQSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336491   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336491
PNG
(US9744172, Compound UNC1319A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C36H40FN7O4S/c1-3-4-21-38-36-40-23-32-33(42-44(34(32)41-36)29-15-17-30(45)18-16-29)25-9-19-31(20-10-25)49(47,48)43(2)28-13-7-26(8-14-28)35(46)39-22-24-5-11-27(37)12-6-24/h5-14,19-20,23,29-30,45H,3-4,15-18,21-22H2,1-2H3,(H,39,46)(H,38,40,41)/t29?,30-
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair