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BDBM336503 US9744172, Compound UNC1347A

SMILES: CCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)N(C)C(CC)=C1C(=O)OC

InChI Key: InChIKey=LRJYHZGAYLWRLX-ZEXMGSOQSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336503   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336503
PNG
(US9744172, Compound UNC1347A)
Show SMILES CCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)N(C)C(CC)=C1C(=O)OC
Show InChI InChI=1S/C29H37N7O4/c1-5-15-30-28-31-16-21-24(34-36(26(21)33-28)19-11-13-20(37)14-12-19)17-7-9-18(10-8-17)25-23(27(38)40-4)22(6-2)35(3)29(39)32-25/h7-10,16,19-20,25,37H,5-6,11-15H2,1-4H3,(H,32,39)(H,30,31,33)/t19?,20-,25?
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PC cid
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US Patent
n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair