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BDBM336506 US9744172, Compound UNC1350A

SMILES: CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)Nc1ccc(F)cc1

InChI Key: InChIKey=LCOVQLQFXFWVJM-KKGVWULHSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336506   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336506
PNG
(US9744172, Compound UNC1350A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C33H40FN7O3/c1-4-5-18-35-33-36-19-27-29(40-41(30(27)39-33)25-14-16-26(42)17-15-25)21-6-8-22(9-7-21)31(43)38-28(20(2)3)32(44)37-24-12-10-23(34)11-13-24/h6-13,19-20,25-26,28,42H,4-5,14-18H2,1-3H3,(H,37,44)(H,38,43)(H,35,36,39)/t25?,26-,28-/m0/s1
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MMDB

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PC cid
PC sid
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US Patent
n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair