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BDBM336512 US9744172, Compound UNC1285A

SMILES: CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCN(CC)CC2)c(F)c1

InChI Key: InChIKey=VNBSIHDGTFVNQU-MEMLXQNLSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336512   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336512
PNG
(US9744172, Compound UNC1285A)
Show SMILES CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCN(CC)CC2)c(F)c1
Show InChI InChI=1S/C27H38FN7O/c1-3-5-12-29-27-30-18-22-25(32-35(26(22)31-27)20-7-9-21(36)10-8-20)19-6-11-24(23(28)17-19)34-15-13-33(4-2)14-16-34/h6,11,17-18,20-21,36H,3-5,7-10,12-16H2,1-2H3,(H,29,30,31)/t20-,21-
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PC cid
PC sid
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US Patent
n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair