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BDBM337233 N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]-2-hydroxy-2-phenylacetamide::US9745304, Example 2

SMILES: OC(C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1

InChI Key: InChIKey=QXPFEBPNDCKVSY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337233   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337233
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES OC(C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C22H16N4O3/c27-21(14-6-2-1-3-7-14)22(28)24-19-10-11-20-23-13-16(26(20)25-19)18-12-15-8-4-5-9-17(15)29-18/h1-13,21,27H,(H,24,25,28)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337233
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES OC(C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C22H16N4O3/c27-21(14-6-2-1-3-7-14)22(28)24-19-10-11-20-23-13-16(26(20)25-19)18-12-15-8-4-5-9-17(15)29-18/h1-13,21,27H,(H,24,25,28)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 7n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
More data for this
Ligand-Target Pair