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BDBM337242 (5S)-1-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]-5-(hydroxymethyl)-pyrrolidin-2-one::US9745304, Example 11

SMILES: OC[C@@H]1CCC(=O)N1c1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=APAZAFAHWYCIQA-ZDUSSCGKSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337242   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337242
PNG
((5S)-1-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...)
Show SMILES OC[C@@H]1CCC(=O)N1c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H16N4O3/c24-11-13-5-8-19(25)22(13)18-7-6-17-20-10-14(23(17)21-18)16-9-12-3-1-2-4-15(12)26-16/h1-4,6-7,9-10,13,24H,5,8,11H2/t13-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337242
PNG
((5S)-1-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...)
Show SMILES OC[C@@H]1CCC(=O)N1c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H16N4O3/c24-11-13-5-8-19(25)22(13)18-7-6-17-20-10-14(23(17)21-18)16-9-12-3-1-2-4-15(12)26-16/h1-4,6-7,9-10,13,24H,5,8,11H2/t13-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair