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BDBM337247 (2S)-2-hydroxy-N-[3-(4-methoxyfuro[3,2-c]pyridin-2-yl)imidazo[1,2-b]pyridazin-6-yl]propanamide::US9745304, Example 16

SMILES: COc1nccc2oc(cc12)-c1cnc2ccc(NC(=O)[C@H](C)O)nn12

InChI Key: InChIKey=PJWUSWRCXKIDCP-VIFPVBQESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337247   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337247
PNG
((2S)-2-hydroxy-N-[3-(4-methoxyfuro[3,2-c]pyridin-2...)
Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(NC(=O)[C@H](C)O)nn12
Show InChI InChI=1S/C17H15N5O4/c1-9(23)16(24)20-14-3-4-15-19-8-11(22(15)21-14)13-7-10-12(26-13)5-6-18-17(10)25-2/h3-9,23H,1-2H3,(H,20,21,24)/t9-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 10n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337247
PNG
((2S)-2-hydroxy-N-[3-(4-methoxyfuro[3,2-c]pyridin-2...)
Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(NC(=O)[C@H](C)O)nn12
Show InChI InChI=1S/C17H15N5O4/c1-9(23)16(24)20-14-3-4-15-19-8-11(22(15)21-14)13-7-10-12(26-13)5-6-18-17(10)25-2/h3-9,23H,1-2H3,(H,20,21,24)/t9-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 10n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair