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BDBM337249 N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]-2-(4-cyanophenyl)-acetamide::US9745304, Example 18

SMILES: O=C(Cc1ccc(cc1)C#N)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=YKEPVEZYTGZSPT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337249   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337249
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(Cc1ccc(cc1)C#N)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C23H15N5O2/c24-13-16-7-5-15(6-8-16)11-23(29)26-21-9-10-22-25-14-18(28(22)27-21)20-12-17-3-1-2-4-19(17)30-20/h1-10,12,14H,11H2,(H,26,27,29)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337249
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(Cc1ccc(cc1)C#N)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C23H15N5O2/c24-13-16-7-5-15(6-8-16)11-23(29)26-21-9-10-22-25-14-18(28(22)27-21)20-12-17-3-1-2-4-19(17)30-20/h1-10,12,14H,11H2,(H,26,27,29)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair