BindingDB logo
myBDB logout

BDBM337250 N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]-3-(1H-imidazol-4-yl)-propanamide::US9745304, Example 19

SMILES: O=C(CCc1c[nH]cn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=BCIIUYDUOQBHKE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337250   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337250
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(CCc1c[nH]cn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H16N6O2/c27-20(8-5-14-10-21-12-23-14)24-18-6-7-19-22-11-15(26(19)25-18)17-9-13-3-1-2-4-16(13)28-17/h1-4,6-7,9-12H,5,8H2,(H,21,23)(H,24,25,27)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337250
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(CCc1c[nH]cn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H16N6O2/c27-20(8-5-14-10-21-12-23-14)24-18-6-7-19-22-11-15(26(19)25-18)17-9-13-3-1-2-4-16(13)28-17/h1-4,6-7,9-12H,5,8H2,(H,21,23)(H,24,25,27)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair