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BDBM337253 N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6-yl]- 3-cyclopropylpropanamide::US9745304, Example 22

SMILES: O=C(CCC1CC1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=MCALTGVZBFASBT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337253   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337253
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES O=C(CCC1CC1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H18N4O2/c25-20(10-7-13-5-6-13)22-18-8-9-19-21-12-15(24(19)23-18)17-11-14-3-1-2-4-16(14)26-17/h1-4,8-9,11-13H,5-7,10H2,(H,22,23,25)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 13n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337253
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES O=C(CCC1CC1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H18N4O2/c25-20(10-7-13-5-6-13)22-18-8-9-19-21-12-15(24(19)23-18)17-11-14-3-1-2-4-16(14)26-17/h1-4,8-9,11-13H,5-7,10H2,(H,22,23,25)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 13n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
More data for this
Ligand-Target Pair