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BDBM337255 N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6-yl]- 1-cyanocyclopropane carboxamide::US9745304, Example 24

SMILES: O=C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1(CC1)C#N

InChI Key: InChIKey=SIRRALRYLSPTEY-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337255   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337255
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES O=C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1(CC1)C#N
Show InChI InChI=1S/C19H13N5O2/c20-11-19(7-8-19)18(25)22-16-5-6-17-21-10-13(24(17)23-16)15-9-12-3-1-2-4-14(12)26-15/h1-6,9-10H,7-8H2,(H,22,23,25)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 25n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337255
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES O=C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1(CC1)C#N
Show InChI InChI=1S/C19H13N5O2/c20-11-19(7-8-19)18(25)22-16-5-6-17-21-10-13(24(17)23-16)15-9-12-3-1-2-4-14(12)26-15/h1-6,9-10H,7-8H2,(H,22,23,25)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 25n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
More data for this
Ligand-Target Pair