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BDBM337258 N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6- yl]tetrahydro-2H-pyran-4- carboxamide::US9745304, Example 27

SMILES: O=C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1CCOCC1

InChI Key: InChIKey=ZHKRRCTXZCUDKD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337258   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337258
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES O=C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1CCOCC1
Show InChI InChI=1S/C20H18N4O3/c25-20(13-7-9-26-10-8-13)22-18-5-6-19-21-12-15(24(19)23-18)17-11-14-3-1-2-4-16(14)27-17/h1-6,11-13H,7-10H2,(H,22,23,25)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337258
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES O=C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1CCOCC1
Show InChI InChI=1S/C20H18N4O3/c25-20(13-7-9-26-10-8-13)22-18-5-6-19-21-12-15(24(19)23-18)17-11-14-3-1-2-4-16(14)27-17/h1-6,11-13H,7-10H2,(H,22,23,25)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair