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BDBM337259 N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6-yl]- N2,N2-dimethylglycinamide::US9745304, Example 28

SMILES: CN(C)CC(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=ZNCQPBAIESXLCS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337259   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337259
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES CN(C)CC(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H17N5O2/c1-22(2)11-18(24)20-16-7-8-17-19-10-13(23(17)21-16)15-9-12-5-3-4-6-14(12)25-15/h3-10H,11H2,1-2H3,(H,20,21,24)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 17n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337259
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES CN(C)CC(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H17N5O2/c1-22(2)11-18(24)20-16-7-8-17-19-10-13(23(17)21-16)15-9-12-5-3-4-6-14(12)25-15/h3-10H,11H2,1-2H3,(H,20,21,24)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 17n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair