BindingDB logo
myBDB logout

BDBM337261 N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6-yl]- 2-(pyrrolidin-1-yl)acetamide::US9745304, Example 30

SMILES: O=C(CN1CCCC1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=RFXGQIZWLZIASR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337261   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337261
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES O=C(CN1CCCC1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H19N5O2/c26-20(13-24-9-3-4-10-24)22-18-7-8-19-21-12-15(25(19)23-18)17-11-14-5-1-2-6-16(14)27-17/h1-2,5-8,11-12H,3-4,9-10,13H2,(H,22,23,26)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 30n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337261
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES O=C(CN1CCCC1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H19N5O2/c26-20(13-24-9-3-4-10-24)22-18-7-8-19-21-12-15(25(19)23-18)17-11-14-5-1-2-6-16(14)27-17/h1-2,5-8,11-12H,3-4,9-10,13H2,(H,22,23,26)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 30n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
More data for this
Ligand-Target Pair