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BDBM337262 N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6-yl]- 3-(3-methylphenyl)propanamide::US9745304, Example 31

SMILES: Cc1cccc(CCC(=O)Nc2ccc3ncc(-c4cc5ccccc5o4)n3n2)c1

InChI Key: InChIKey=KDJGBGJDYGZBCB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337262   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337262
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES Cc1cccc(CCC(=O)Nc2ccc3ncc(-c4cc5ccccc5o4)n3n2)c1
Show InChI InChI=1S/C24H20N4O2/c1-16-5-4-6-17(13-16)9-12-24(29)26-22-10-11-23-25-15-19(28(23)27-22)21-14-18-7-2-3-8-20(18)30-21/h2-8,10-11,13-15H,9,12H2,1H3,(H,26,27,29)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 67n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337262
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES Cc1cccc(CCC(=O)Nc2ccc3ncc(-c4cc5ccccc5o4)n3n2)c1
Show InChI InChI=1S/C24H20N4O2/c1-16-5-4-6-17(13-16)9-12-24(29)26-22-10-11-23-25-15-19(28(23)27-22)21-14-18-7-2-3-8-20(18)30-21/h2-8,10-11,13-15H,9,12H2,1H3,(H,26,27,29)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 67n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
BindingDB Entry DOI: 10.7270/Q2D79DHV
More data for this
Ligand-Target Pair