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BDBM337263 N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6-yl]- 2-(4-methylpiperidin-1- yl)acetamide::US9745304, Example 32

SMILES: CC1CCN(CC(=O)Nc2ccc3ncc(-c4cc5ccccc5o4)n3n2)CC1

InChI Key: InChIKey=QSNZOIMTTIUEHU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337263   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337263
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES CC1CCN(CC(=O)Nc2ccc3ncc(-c4cc5ccccc5o4)n3n2)CC1
Show InChI InChI=1S/C22H23N5O2/c1-15-8-10-26(11-9-15)14-22(28)24-20-6-7-21-23-13-17(27(21)25-20)19-12-16-4-2-3-5-18(16)29-19/h2-7,12-13,15H,8-11,14H2,1H3,(H,24,25,28)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 17n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337263
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES CC1CCN(CC(=O)Nc2ccc3ncc(-c4cc5ccccc5o4)n3n2)CC1
Show InChI InChI=1S/C22H23N5O2/c1-15-8-10-26(11-9-15)14-22(28)24-20-6-7-21-23-13-17(27(21)25-20)19-12-16-4-2-3-5-18(16)29-19/h2-7,12-13,15H,8-11,14H2,1H3,(H,24,25,28)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 17n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
More data for this
Ligand-Target Pair