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BDBM337292 (R)-3-(ethylamino)-6-(1-phenylethyl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one::US9745307, Example 29

SMILES: CCNC(=N)c1cc2CN([C@H](C)c3ccccc3)C(=O)Nc2cc1N

InChI Key: InChIKey=NSLKFHYYWCOTPL-GFCCVEGCSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 337292   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM337292
PNG
((R)-3-(ethylamino)-6-(1-phenylethyl)-5,6-dihydro-1...)
Show SMILES CCNC(=N)c1cc2CN([C@H](C)c3ccccc3)C(=O)Nc2cc1N
Show InChI InChI=1S/C19H23N5O/c1-3-22-18(21)15-9-14-11-24(12(2)13-7-5-4-6-8-13)19(25)23-17(14)10-16(15)20/h4-10,12H,3,11,20H2,1-2H3,(H2,21,22)(H,23,25)/t12-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 22n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...


US Patent US9745307 (2017)

More data for this
Ligand-Target Pair