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BDBM337347 4-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)-N,N-dimethylpicolinamide::US9745311, Example 74

SMILES: COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccnc(c2)C(=O)N(C)C)cc(OC)c1

InChI Key: InChIKey=RHUXGTOJWZCVSV-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 337347   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337347
PNG
(4-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccnc(c2)C(=O)N(C)C)cc(OC)c1
Show InChI InChI=1S/C24H25N5O3/c1-29(2)24(30)22-11-16(7-8-25-22)20-13-21-23(28-20)26-14-17(27-21)6-5-15-9-18(31-3)12-19(10-15)32-4/h7-14H,5-6H2,1-4H3,(H,26,28)
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM337347
PNG
(4-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccnc(c2)C(=O)N(C)C)cc(OC)c1
Show InChI InChI=1S/C24H25N5O3/c1-29(2)24(30)22-11-16(7-8-25-22)20-13-21-23(28-20)26-14-17(27-21)6-5-15-9-18(31-3)12-19(10-15)32-4/h7-14H,5-6H2,1-4H3,(H,26,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337347
PNG
(4-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyr...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccnc(c2)C(=O)N(C)C)cc(OC)c1
Show InChI InChI=1S/C24H25N5O3/c1-29(2)24(30)22-11-16(7-8-25-22)20-13-21-23(28-20)26-14-17(27-21)6-5-15-9-18(31-3)12-19(10-15)32-4/h7-14H,5-6H2,1-4H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair