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BDBM337376 5-[4-(3,4-Dihydro-2H-pyrano[3,2-c]pyridin-5-yloxy)-2-methylphenyl]-4,6-dimethylpyridazin-3(2H)-one (14)::US9745317, 14

SMILES: CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Cc2c(cccc12)P(c1ccccc1)c1ccccc1

InChI Key: InChIKey=XPJKWTOMGVDRDJ-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 337376   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM337376
PNG
(5-[4-(3,4-Dihydro-2H-pyrano[3,2-c]pyridin-5-yloxy)...)
Show SMILES CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Cc2c(cccc12)P(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C40H34P2/c1-40(2)36-25-15-27-38(41(30-17-7-3-8-18-30)31-19-9-4-10-20-31)34(36)29-35-37(40)26-16-28-39(35)42(32-21-11-5-12-22-32)33-23-13-6-14-24-33/h3-28H,29H2,1-2H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
70.3n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9745317 (2017)


Article DOI: 10.1021/jm049187l
More data for this
Ligand-Target Pair