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BDBM337381 US9745317, 19

SMILES: Cc1cc(Oc2ncnc3NCCc23)ccc1-c1c(C)ncnc1C

InChI Key: InChIKey=NRGROSVUDAECNS-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 337381   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM337381
PNG
(US9745317, 19)
Show SMILES Cc1cc(Oc2ncnc3NCCc23)ccc1-c1c(C)ncnc1C
Show InChI InChI=1S/C19H19N5O/c1-11-8-14(25-19-16-6-7-20-18(16)23-10-24-19)4-5-15(11)17-12(2)21-9-22-13(17)3/h4-5,8-10H,6-7H2,1-3H3,(H,20,23,24)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
156n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9745317 (2017)


Article DOI: 10.1021/jm049187l
BindingDB Entry DOI: 10.7270/Q2W95CBQ
More data for this
Ligand-Target Pair