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BDBM337635 6-Cyclohexyl-4-hydroxypyridazin-3(2H)-one::BDBM50431072::US9750748, 7

SMILES: Oc1cc(n[nH]c1=O)C1CCCCC1

InChI Key:

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 337635   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D-amino-acid oxidase


(Homo sapiens (human))
BDBM337635
PNG
(6-Cyclohexyl-4-hydroxypyridazin-3(2H)-one | BDBM50...)
Show SMILES Oc1cc(n[nH]c1=O)C1CCCCC1
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis


J Med Chem 56: 3582-92 (2013)


Article DOI: 10.1021/jm400095b
BindingDB Entry DOI: 10.7270/Q2HT2QPZ
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (human))
BDBM337635
PNG
(6-Cyclohexyl-4-hydroxypyridazin-3(2H)-one | BDBM50...)
Show SMILES Oc1cc(n[nH]c1=O)C1CCCCC1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DAAO after 30 mins by plate reader analysis


J Med Chem 56: 3582-92 (2013)


Article DOI: 10.1021/jm400095b
BindingDB Entry DOI: 10.7270/Q2HT2QPZ
More data for this
Ligand-Target Pair
D-amino-acid oxidase (DAAO)


(Homo sapiens (human))
BDBM337635
PNG
(6-Cyclohexyl-4-hydroxypyridazin-3(2H)-one | BDBM50...)
Show SMILES Oc1cc(n[nH]c1=O)C1CCCCC1
PDB
MMDB

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UniProtKB/SwissProt

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DrugBank
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UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2, which ...


US Patent US9750748 (2017)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Mus musculus)
BDBM337635
PNG
(6-Cyclohexyl-4-hydroxypyridazin-3(2H)-one | BDBM50...)
Show SMILES Oc1cc(n[nH]c1=O)C1CCCCC1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis


J Med Chem 56: 3582-92 (2013)


Article DOI: 10.1021/jm400095b
BindingDB Entry DOI: 10.7270/Q2HT2QPZ
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Rattus norvegicus (rat))
BDBM337635
PNG
(6-Cyclohexyl-4-hydroxypyridazin-3(2H)-one | BDBM50...)
Show SMILES Oc1cc(n[nH]c1=O)C1CCCCC1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis


J Med Chem 56: 3582-92 (2013)


Article DOI: 10.1021/jm400095b
BindingDB Entry DOI: 10.7270/Q2HT2QPZ
More data for this
Ligand-Target Pair