BDBM338842 US9751886, Compound 7

SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(OCF)cn2)ccc1F

InChI Key InChIKey=IFZVTLKVMBOTCD-IBGZPJMESA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 338842   

TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338842(US9751886, Compound 7)
Affinity DataIC50:  1.00E+9nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338842(US9751886, Compound 7)
Affinity DataIC50:  16.6nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the ¿Swedish¿ Lys-Met/Asn-Leu ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338842(US9751886, Compound 7)
Affinity DataIC50:  3.02nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent