BDBM339593 US10202339, Compound 37
SMILES FC(F)(F)CNS(=O)(=O)c1ccc(c(NC(=O)Nc2ccc(Cl)cc2)c1)-c1ccccc1
InChI Key InChIKey=PUKSIBFVRFOAAM-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 339593
TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Homo sapiens (Human))
Agios Pharmaceuticals
US Patent
Agios Pharmaceuticals
US Patent
Affinity DataIC50: 550nMAssay Description:Compounds were assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds were preincubated with enzyme, then the react...More data for this Ligand-Target Pair