BDBM33963 vinylogous urea, NSC727448

SMILES Cc1sc(NC(=O)c2ccco2)c(C(N)=O)c1C

InChI Key InChIKey=ACRJYJHXXHYAJP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 33963   

TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

LigandPNGBDBM33963(vinylogous urea, NSC727448)
Affinity DataIC50:  3.20E+3nMpH: 8.0 T: 2°CAssay Description:RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonuclease H1(Homo sapiens (Human))
National Cancer Institute-Bethesda

LigandPNGBDBM33963(vinylogous urea, NSC727448)
Affinity DataIC50:  2.90E+4nMpH: 8.0 T: 2°CAssay Description:RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonuclease HI(Escherichia coli (strain K12))
National Cancer Institute-Bethesda

LigandPNGBDBM33963(vinylogous urea, NSC727448)
Affinity DataIC50:  7.30E+4nMpH: 8.0 T: 2°CAssay Description:RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D](Human immunodeficiency virus type 2)
National Cancer Institute-Bethesda

LigandPNGBDBM33963(vinylogous urea, NSC727448)
Affinity DataIC50:  5.00E+3nMpH: 8.0 T: 2°CAssay Description:RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed