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BDBM339663 US10202339, Compound 108

SMILES: FC(F)(F)CNS(=O)(=O)c1ccc(c(NC(=O)n2ccc3ccccc23)c1)-c1ccccc1

InChI Key: InChIKey=GMOSWTXVEDNAGA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339663   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
IDH2(R140Q)


(Homo sapiens (Human))
BDBM339663
PNG
(US10202339, Compound 108)
Show SMILES FC(F)(F)CNS(=O)(=O)c1ccc(c(NC(=O)n2ccc3ccccc23)c1)-c1ccccc1
Show InChI InChI=1S/C23H18F3N3O3S/c24-23(25,26)15-27-33(31,32)18-10-11-19(16-6-2-1-3-7-16)20(14-18)28-22(30)29-13-12-17-8-4-5-9-21(17)29/h1-14,27H,15H2,(H,28,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Agios Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds were preincubated with enzyme, then the react...


US Patent US10202339 (2019)

More data for this
Ligand-Target Pair