BDBM339730 US10202339, Compound 352
SMILES Cc1ccc(NC(=O)Nc2c(Cl)cccc2Cl)cc1S(=O)(=O)Nc1ccc(Cl)cc1
InChI Key InChIKey=RUOWCMKZYRJANY-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 339730
TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Homo sapiens (Human))
Agios Pharmaceuticals
US Patent
Agios Pharmaceuticals
US Patent
Affinity DataIC50: 550nMAssay Description:Compounds were assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds were preincubated with enzyme, then the react...More data for this Ligand-Target Pair