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BDBM339970 (R)-tert-butyl (1-((6-chloro-5-cyanopyrazin-2-yl)amino)-3-methoxypropan-2-yl)carbamate::US9775839, 1.1

SMILES: COC[C@@H](CNc1cnc(C#N)c(Cl)n1)NC(=O)OC(C)(C)C

InChI Key: InChIKey=WPQPXRZNTONAIZ-SECBINFHSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339970   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339970
PNG
((R)-tert-butyl (1-((6-chloro-5-cyanopyrazin-2-yl)a...)
Show SMILES COC[C@@H](CNc1cnc(C#N)c(Cl)n1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C14H20ClN5O3/c1-14(2,3)23-13(21)19-9(8-22-4)6-18-11-7-17-10(5-16)12(15)20-11/h7,9H,6,8H2,1-4H3,(H,18,20)(H,19,21)/t9-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 528n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair