BindingDB logo
myBDB logout

BDBM339975 (S)-5-((2-Aminopropyl)amino)-3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-indol-2-yl)pyrazine-2-carboxamide::US9775839, 5.1

SMILES: C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(ccc2[nH]1)-c1cnn(C)c1

InChI Key:

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339975   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339975
PNG
((S)-5-((2-Aminopropyl)amino)-3-(5-(1-methyl-1H-pyr...)
Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(ccc2[nH]1)-c1cnn(C)c1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair