BindingDB logo
myBDB logout

BDBM339988 5-{[(3R,4R)-4-amino-1,1- dioxidotetrahydro-2H- thiopyran-3-yl]amino}-3- (1H-indol-2-yl)pyrazine-2- carboxamide::US9775839, 8.2

SMILES: N[C@@H]1CCS(=O)(=O)C[C@@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1

InChI Key:

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339988   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM339988
PNG
(5-{[(3R,4R)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Show SMILES N[C@@H]1CCS(=O)(=O)C[C@@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 124n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair