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BDBM340012 (S)-5-((1-amino-3- methoxypropan-2- yl)amino)-3-(1H-indol-2- yl)pyrazine-2-carboxamide::US9775839, 16.2

SMILES: COC[C@H](CN)Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1

InChI Key:

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340012   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM340012
PNG
((S)-5-((1-amino-3- methoxypropan-2- yl)amino)-3-(1...)
Show SMILES COC[C@H](CN)Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 27.2n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...


US Patent US9775839 (2017)

More data for this
Ligand-Target Pair