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BDBM340044 2-[2-Methyl-5-(trifluoromethoxy)-2H-indazol-3-yl]-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid::US9758517, Example 5

SMILES: Cn1nc2ccc(OC(F)(F)F)cc2c1-c1cc2nccc(C(O)=O)c2[nH]1

InChI Key: InChIKey=SCUUPOSRGFEJMP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340044   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340044
PNG
(2-[2-Methyl-5-(trifluoromethoxy)-2H-indazol-3-yl]-...)
Show SMILES Cn1nc2ccc(OC(F)(F)F)cc2c1-c1cc2nccc(C(O)=O)c2[nH]1
Show InChI InChI=1S/C17H11F3N4O3/c1-24-15(10-6-8(27-17(18,19)20)2-3-11(10)23-24)13-7-12-14(22-13)9(16(25)26)4-5-21-12/h2-7,22H,1H3,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair