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BDBM340045 2-(5-Cyclopropyl-2-methyl-2H-indazol-3-yl)-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid::US10231957, Example 6::US9758517, Example 6

SMILES: Cn1nc2ccc(cc2c1-c1cc2nccc(C(O)=O)c2[nH]1)C1CC1

InChI Key: InChIKey=QAMDAKQAZORFLD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 340045   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM340045
PNG
(2-(5-Cyclopropyl-2-methyl-2H-indazol-3-yl)-1H-pyrr...)
Show SMILES Cn1nc2ccc(cc2c1-c1cc2nccc(C(O)=O)c2[nH]1)C1CC1
Show InChI InChI=1S/C19H16N4O2/c1-23-18(13-8-11(10-2-3-10)4-5-14(13)22-23)16-9-15-17(21-16)12(19(24)25)6-7-20-15/h4-10,21H,2-3H2,1H3,(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit JMJD2C demethylase activity. Baculovirus expressed JMIJD2C (GenBank Accession #BC1435...


US Patent US10231957 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340045
PNG
(2-(5-Cyclopropyl-2-methyl-2H-indazol-3-yl)-1H-pyrr...)
Show SMILES Cn1nc2ccc(cc2c1-c1cc2nccc(C(O)=O)c2[nH]1)C1CC1
Show InChI InChI=1S/C19H16N4O2/c1-23-18(13-8-11(10-2-3-10)4-5-14(13)22-23)16-9-15-17(21-16)12(19(24)25)6-7-20-15/h4-10,21H,2-3H2,1H3,(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)


Article DOI: 10.1021/jm0303857
BindingDB Entry DOI: 10.7270/Q2RB76QF
More data for this
Ligand-Target Pair