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BDBM340049 2-[6-Chloro-2-(cyclopropylmethyl)-2H-indazol-3-yl]-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid::US9758517, Example 9

SMILES: OC(=O)c1ccnc2cc([nH]c12)-c1n(CC2CC2)nc2cc(Cl)ccc12

InChI Key: InChIKey=WIEFDLPLATYION-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340049   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340049
PNG
(2-[6-Chloro-2-(cyclopropylmethyl)-2H-indazol-3-yl]...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1n(CC2CC2)nc2cc(Cl)ccc12
Show InChI InChI=1S/C19H15ClN4O2/c20-11-3-4-12-14(7-11)23-24(9-10-1-2-10)18(12)16-8-15-17(22-16)13(19(25)26)5-6-21-15/h3-8,10,22H,1-2,9H2,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair