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BDBM340050 2-{5-Chloro-2-[2-(pyrrolidin-1-yl)ethyl]-2H-indazol-3-yl}-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid::US9758517, Example 10

SMILES: OC(=O)c1ccnc2cc([nH]c12)-c1n(CCN2CCCC2)nc2ccc(Cl)cc12

InChI Key: InChIKey=CMDUWYJKEZDBRT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340050   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340050
PNG
(2-{5-Chloro-2-[2-(pyrrolidin-1-yl)ethyl]-2H-indazo...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1n(CCN2CCCC2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H20ClN5O2/c22-13-3-4-16-15(11-13)20(27(25-16)10-9-26-7-1-2-8-26)18-12-17-19(24-18)14(21(28)29)5-6-23-17/h3-6,11-12,24H,1-2,7-10H2,(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair