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BDBM340051 2-{2-Methyl-6-[methyl(phenyl)amino]-2H-indazol-3-yl}-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid::US10231957, Example 11::US9758517, Example 11

SMILES: CN(c1ccccc1)c1ccc2c(-c3cc4nccc(C(O)=O)c4[nH]3)n(C)nc2c1

InChI Key: InChIKey=BCHHWANJSHBCCY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 340051   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM340051
PNG
(2-{2-Methyl-6-[methyl(phenyl)amino]-2H-indazol-3-y...)
Show SMILES CN(c1ccccc1)c1ccc2c(-c3cc4nccc(C(O)=O)c4[nH]3)n(C)nc2c1
Show InChI InChI=1S/C23H19N5O2/c1-27(14-6-4-3-5-7-14)15-8-9-16-18(12-15)26-28(2)22(16)20-13-19-21(25-20)17(23(29)30)10-11-24-19/h3-13,25H,1-2H3,(H,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit JMJD2C demethylase activity. Baculovirus expressed JMIJD2C (GenBank Accession #BC1435...


US Patent US10231957 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340051
PNG
(2-{2-Methyl-6-[methyl(phenyl)amino]-2H-indazol-3-y...)
Show SMILES CN(c1ccccc1)c1ccc2c(-c3cc4nccc(C(O)=O)c4[nH]3)n(C)nc2c1
Show InChI InChI=1S/C23H19N5O2/c1-27(14-6-4-3-5-7-14)15-8-9-16-18(12-15)26-28(2)22(16)20-13-19-21(25-20)17(23(29)30)10-11-24-19/h3-13,25H,1-2H3,(H,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)


Article DOI: 10.1021/jm0303857
BindingDB Entry DOI: 10.7270/Q2RB76QF
More data for this
Ligand-Target Pair