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BDBM340056 2-(6-Fluoro-1-methyl-1H-indazol-3-yl)-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid::US9758517, Example 16

SMILES: Cn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2ccc(F)cc12

InChI Key: InChIKey=RDQLNICRVWZWBF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340056   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340056
PNG
(2-(6-Fluoro-1-methyl-1H-indazol-3-yl)-1H-pyrrolo[3...)
Show SMILES Cn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2ccc(F)cc12
Show InChI InChI=1S/C16H11FN4O2/c1-21-13-6-8(17)2-3-9(13)15(20-21)12-7-11-14(19-12)10(16(22)23)4-5-18-11/h2-7,19H,1H3,(H,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 550n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)


Article DOI: 10.1021/jm0303857
More data for this
Ligand-Target Pair