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BDBM340057 2-(6-Chloro-1-ethyl-1H-indazol-3-yl)-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid::US9758517, Example 17

SMILES: CCn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2ccc(Cl)cc12

InChI Key: InChIKey=FYPRAAAVKRFZBE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340057   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340057
PNG
(2-(6-Chloro-1-ethyl-1H-indazol-3-yl)-1H-pyrrolo[3,...)
Show SMILES CCn1nc(-c2cc3nccc(C(O)=O)c3[nH]2)c2ccc(Cl)cc12
Show InChI InChI=1S/C17H13ClN4O2/c1-2-22-14-7-9(18)3-4-10(14)16(21-22)13-8-12-15(20-13)11(17(23)24)5-6-19-12/h3-8,20H,2H2,1H3,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair