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BDBM340058 2-[6-Chloro-1-(cyclopropylmethyl)-1H-indazol-3-yl]-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid::US10231957, Example 18::US9758517, Example 18

SMILES: OC(=O)c1ccnc2cc([nH]c12)-c1nn(CC2CC2)c2cc(Cl)ccc12

InChI Key: InChIKey=KTDKEUFKBALDGF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 340058   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM340058
PNG
(2-[6-Chloro-1-(cyclopropylmethyl)-1H-indazol-3-yl]...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1nn(CC2CC2)c2cc(Cl)ccc12
Show InChI InChI=1S/C19H15ClN4O2/c20-11-3-4-12-16(7-11)24(9-10-1-2-10)23-18(12)15-8-14-17(22-15)13(19(25)26)5-6-21-14/h3-8,10,22H,1-2,9H2,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
This assay determines the ability of a test compound to inhibit JMJD2C demethylase activity. Baculovirus expressed JMIJD2C (GenBank Accession #BC1435...


US Patent US10231957 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340058
PNG
(2-[6-Chloro-1-(cyclopropylmethyl)-1H-indazol-3-yl]...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1nn(CC2CC2)c2cc(Cl)ccc12
Show InChI InChI=1S/C19H15ClN4O2/c20-11-3-4-12-16(7-11)24(9-10-1-2-10)23-18(12)15-8-14-17(22-15)13(19(25)26)5-6-21-14/h3-8,10,22H,1-2,9H2,(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)


Article DOI: 10.1021/jm0303857
BindingDB Entry DOI: 10.7270/Q2RB76QF
More data for this
Ligand-Target Pair