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BDBM340059 2-[6-Chloro-1-(2,2,2-trifluoroethyl)-1H-indazol-3-yl]-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid::US9758517, Example 19

SMILES: OC(=O)c1ccnc2cc([nH]c12)-c1nn(CC(F)(F)F)c2cc(Cl)ccc12

InChI Key: InChIKey=DQEYGOAPDFLPMU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340059   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C (JMJD2C)


(Homo sapiens (Human))
BDBM340059
PNG
(2-[6-Chloro-1-(2,2,2-trifluoroethyl)-1H-indazol-3-...)
Show SMILES OC(=O)c1ccnc2cc([nH]c12)-c1nn(CC(F)(F)F)c2cc(Cl)ccc12
Show InChI InChI=1S/C17H10ClF3N4O2/c18-8-1-2-9-13(5-8)25(7-17(19,20)21)24-15(9)12-6-11-14(23-12)10(16(26)27)3-4-22-11/h1-6,23H,7H2,(H,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9758517 (2017)

More data for this
Ligand-Target Pair